eneric name: Adapalene Brand name: Zonalene (by Horizon Pharmaceuticals) Strength: 0.1% cream Pack size: 15g tube Category: Dermatology → Acne Care Mechanism of Action Adapalene is a third‑generation retinoid. It works by modulating skin cell differentiation and keratinization, preventing clogged pores and reducing inflammation. Improves overall skin texture and reduces acne lesions. Clinical Uses Acne vulgaris → effective for mild to moderate acne. Comedonal acne → reduces blackheads and whiteheads. Side Effects Common: Redness, dryness, peeling, mild burning. Rare: Severe irritation or allergic reaction. Precautions: Avoid excessive sun exposure; use sunscreen. Not recommended during pregnancy. Patient Counselling Points Apply a thin layer at night to affected areas. Wash face gently before application. Use moisturizer to reduce dryness. Improvement may take 8–12 weeks; continue as prescribed. Store below 30°C, away from sunlight and moisture.